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At the same time, payer policies often require discontinuation of GLP-1 therapy when a patients BMI drops below a set threshold, inadvertently triggering a frustrating cycle of weight loss and regainthe so-called yo-yo effect. This not only impacts ongoing adherence and persistence but also undermines the long-term cost-effectiveness of these therapies for healthcare systems

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The expression long-term describes the course of body weight observed over a period of at least 1 year on themaintenance dose of the drug

Foldi and Griffiths consider how interdisciplinary research, dimensional diagnostic approaches and improved animal models may enable the development of more effective treatments for these disorders.