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20222023: Tirzepatide and the SURMOUNT Trials Tirzepatide (Mounjaro) raised the bar

Active studies can be located through clinicaltrials.gov, with eligibility determinations made through healthcare provider consultation

More concerning still, the prevalence of severe obesity, defined as a BMI 35 kg/m 2 with at least one comorbidity or a BMI 40, was 9.7% [6]

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The next wave dual and triple agonists (GLP-1 + GIP + glucagon: tirzepatide, retatrutide, survodutide) are showing superior fat loss, better hepatic outcomes, and potentially preserved lean mass