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First, a decrease in hepatic glucose production can only partially account for the decrease in blood glucose (48)

29 , 40 Asimismo, los iSGLT2 tambin producen aumento del glucagn, gluconeognesis heptica 29 , 41 y riesgo de cetoacidosis euglucmica, efectos que podran contrarrestarse con los AGLP1, dando soporte fisiolgico a su combinacin

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The first is that the generic version is somehow inferior to the brand name