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The two agents may be started simultaneously or sequentially , depending on clinical circumstances and patient factors

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Dietary fibre, particularly soluble types, stimulates GLP-1 release through short-chain fatty acids produced by gut bacteria fermenting fibre

In addition to the results from SURPASS 4, which was designed to provide preliminary evidence for the cardiovascular safety of tirzepatide, a separate analysis pooling all the clinical trials with tirzepatide was used to generate a pre-specified estimate of cardiovascular events [20] (Table 1)

Long-term research will also guide clinical guidelines by clarifying maintenance strategies, cardiovascular outcomes, and optimal discontinuation protocols all of which affect value calculations for patients and payers