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Dulaglutide and lixisenatide showed relatively lower overall GI tolerability burden
Krieger JP (2020) Intestinal glucagon-like peptide-1 effects on food intake: Physiological relevance and emerging mechanisms

This hormone activates GLP-1 receptors in the enteric nervous system and through vagal pathways that influence digestive function
97 , E1165E1169 (2012)

The activation of GLP-1R promotes the release of -endorphins, which mediate analgesic effects through receptors at the neuronal level [39, 42]