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Our previous studies have demonstrated that exendin-4 therapy can protect the kidneys and preserve renal function in response to ischemia-reperfusion injury by upregulating antioxidants, and reducing inflammation, oxidative stress and fibrosis (30-34)

Obesity is also a leading driver of gastrointestinal (GI) and hepatobiliary cancers, from colorectal cancer to hepatocellular carcinoma, making any therapy that modifies obesity-related cancer risk directly relevant to gastroenterology practice

Patients taking tirzepatide 10 mg achieved an average of 19.5% weight loss, and patients taking tirzepatide 15 mg achieved an average of 20.9% weight loss

While compounded alternatives gained traction when there were supply constraints, the FDAs intervention highlights the regulatory and evidentiary advantages of approved therapies including FDA-reviewed labeling, established safety and efficacy data, and regulated manufacturing oversight

For HR and benefits leaders weighing employee interest with potential cost impact, ensuring the right patient gets the right drug at the right time is more critical than ever, says Mark Campbell, chief pharmacy officer at RxBenefits