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It should be noted that findings of subgroup analyses should not be regarded as conclusive, their credibility should always be formally assessed and, ideally, they should be complemented by findings from relevant RCTs [7, 8]

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99 In EXSCEL, a post hoc analysis which evaluated the combination of SGLT2 inhibitors and once-weekly exenatide, improvements in all-cause mortality and major adverse cardiovascular events were observed in addition to a nominal significant improvement in preventing decline in eGFR in comparison to patients not on SGLT2 inhibitors

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