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Ligand-specific factors influencing glp-1 receptor post-endocytic trafficking and degradation in pancreatic beta cells
These studies established its safety profile, optimal dosing, and effectiveness for both diabetes management and weight loss
Additional comparative evidence comes from: A 2025 narrative review synthesising randomised and indirect comparison data across obesity and type 2 diabetes trials, confirming tirzepatides superiority on weight and HbA1c [2]
B., Rijkers, A
Some plateaus last only a few weeks, while others continue longer depending on lifestyle factors, medication dose, and individual metabolism
