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Linzess has been studied and approved for long-term use in managing chronic conditions like IBS-C and CIC

Evidence Rating Level: 1 (Excellent) Study Rundown: Patients with overweight or obese body-mass-indices (BMIs) often struggle with weight management on conservative therapy

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has received consulting fees on behalf of Newcastle University from 89bio, Akero, Alimentiv, AstraZeneca, Axcella, Boehringer Ingelheim, Bristol Myers Squibb, Galmed, Genentech, Genfit, Gilead, GlaxoSmithKline, Hanmi, HistoIndex, Intercept, Inventiva, Ionis, IQVIA, Janssen, Madrigal, Medpace, Merck, NGMBio, Novartis, Novo Nordisk, PathAI, Pfizer, Pharmanest, Poxel, Prosciento, Resolution Therapeutics, Ridgeline Therapeutics, Roche, RTI, Shionogi and Terns Pharmaceuticals

To address this limitation, future research could explore alternative approaches to threshold selection and analysis