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Semaglutide injection works by slowing stomach emptying and signaling fullness to the brain, which often causes temporary nausea, constipation, or fatigue during the first 24 weeks

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Energy balance is regulated in the central nervous system command centerthe hypothalamus, specifically the arcuate nucleus, which is responsible for sensing energy status and controlling caloric intake and expenditure through orexigenic and anorexigenic neuropeptides [45, 46]

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