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10.1001/jama.2014.5988 [EL 2

The effects appear potentially larger than current FDA-approved options, though head-to-head trials haven't yet been conducted

Food helps reduce metformin-related nausea, diarrhea, cramping, and appetite changes

doi: 10.1073/pnas.0707054104

The main outcomes are the first-time diagnosis of (1) overall ADRD (International Classification of Diseases, Tenth Revision (ICD-10) code F01 Vascular dementia, G31.0 Frontotemporal dementia, G31.83 Neurocognitive disorder with Lewy bodies, F03 Unspecified dementia, F02 Dementia in other diseases classified elsewhere), (2) vascular dementia (F01 Vascular dementia), (3) FTD (G31.0 Frontotemporal dementia), (4) LBD (G31.83 Neurocognitive disorder with Lewy bodies), and (5) other dementias (F03 Unspecified dementia, F02 Dementia in other diseases classified elsewhere)