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Description
Trials showed lixisenatide lowered A1c by ~0.7% and helped with a modest weight loss (~23 kg) when added to oral meds ( [63] )

The protective and antiinflammatory effects of a modified glucagon-like peptide-2 dimer in inflammatory bowel disease

Coverage denials are common when the indication is weight loss alone rather than diabetes
It has been around since 1959, making it one of the longest-standing FDA-approved weight loss medications in the United States

Yes, most side effects diminish significantly or resolve completely within 8-12 weeks
