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In addition, the leptin-receptor-expressing (LepR) neural activity in the dorsomedial hypothalamus (DMH), which sends GABAergic inhibitory inputs to ARC AgRP neurons, is also known to be rapidly increased by sensory detection, the taste of food, or food cues [48,53,54]

Ozempic is FDA-approved for type 2 diabetes, not weight management

Those same actions especially the slowed stomach emptying are what drive nausea, and the gut adapts to them only gradually

Ozempic is usually administered once a week via subcutaneous injection

doi: 10.1210/endo-84-6-1484