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It was demonstrated that in a mouse model of SCI, melatonin displayed anti-inflammatory effects by reducing the upregulation of IL-17, interferon-gamma (IFN- ) and monocyte chemoattractant protein-1 (MCP1) (Jing et al., 2019)

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Levay M, Krobert KA, Wittig K, Voigt N, Bermudez M, Wolber G, Dobrev D, Levy FO, Wieland T (2013) NSC23766, a widely used inhibitor of Rac1 activation, additionally acts as a competitive antagonist at muscarinic acetylcholine receptors
In this regard, it has been suggested that proliferation of jejunal enteroendocrine L cells could contribute to this response [27]

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