mechanism of action of glp 1 receptor agonists Glucagon-like peptide agonists: cardiovascular benefits and mechanisms GLP-1RAs Reduce External Eating Behavior
Description
Kaku K, Yamada Y, Watada H, et al
Involvement of steatosis-induced glucagon resistance in hyperglucagonaemia
That suggests the amylin and GLP-1 pathways create a synergistic interaction, not just a combined one
This warning stems from studies in rodents where these medications caused dose-dependent and treatment-duration-dependent increases in thyroid C-cell tumors, including medullary thyroid carcinoma (MTC), at clinically relevant exposures
The difference is FDA approval: Mounjaro is approved for type 2 diabetes, and Zepbound is approved for chronic weight management
