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For most healthy adults, it is reasonably well tolerated

They draw water into the bowel, softening stools and increasing frequency Bulk-forming laxatives (ispaghula husk, methylcellulose) work similarly to dietary fibre and are generally suitable for long-term use, but should be avoided if you have severe bloating or suspected impaction Stimulant laxatives (senna, bisacodyl) should be reserved for short-term use when other measures fail Rectal treatments (glycerol suppositories, small-volume enemas) can provide rapid relief for occasional constipation Establishing a regular toilet routine can be beneficial

A switch would always require starting semaglutide at its lowest dose and titrating up, unless instructed otherwise by your provider

Its unique mechanism of action provides additional metabolic benefits, such as improved glucose control and appetite suppression, making it appealing for both weight loss and diabetes management

These divergent findings likely reflect heterogeneity in study design, mechanisms of action of the drugs evaluated, duration of follow-up, and the degree of metabolic phenotyping across populations