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strongest dose of semaglutide How to Use Ozempic® Pen STEP-UP: A New Highest Dose
Description
Materials and Methods Animals, diets, PH and treatments 8 week-old male C57Bl/6 mice were fed a chow diet or MCD diet (TD-90262 Harlan-Tecklad, Indianapolis, USA) for one week, at which time liver damage is already observed 27

Clinical trials have demonstrated substantial weight loss in obesity studiesapproximately 15% at 5 mg, 19.5% at 10 mg, and 20.9% at 15 mg after 72 weeks of treatment

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The following is one example of a titration schedule used in Phase 2 protocols it does not represent a single universal regimen, and other escalation speeds were also evaluated: Weeks 14: 2 mg once weekly (initiation dose) Weeks 58: 4 mg once weekly Weeks 912: 8 mg once weekly Week 13 onwards: 12 mg once weekly (where tolerated) This gradual up-titration mirrors the approach used with approved agents such as semaglutide and tirzepatide, where slow dose escalation is essential to improve gastrointestinal tolerability
Van Cauwenberghe et al
