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retatrutide and type 1 diabetes Retatrutide, a GIP, GLP-1 glucagon receptor agonist, for people with 2 diabetes: a randomised, double-blind, placebo and active-controlled, parallel-group, phase 2 trial conducted in the USA Survodutide vs. Retatrutide for Weight
Description
Fatigue does not increase linearly with dose

One additional detail about bupropion that becomes relevant when combined with GLP-1 therapy concerns its effect on energy

While these typically do not require immediate intervention, they should be monitored, and patients should be counseled about symptoms that would necessitate treatment
doi: 10.1096/fj.12-222695 44 Garca NoresGDLyCLCuzzoneDAKataruRPHespeGETorrisiJSet al

This might relate to GIPs potential effects on food reward pathways or metabolic signaling
