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Tirzepatide at 20.9% weight loss (SURMOUNT-1, Jastreboff et al

Many patients also experience improved mobility, fewer aches and pains, better mood, and increased motivation to maintain healthy eating and exercise habits

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Semaglutide launched as Ozempic in 2017 for Type 2 diabetes, but observed weight loss prompted a phase II obesity trial in 2015

Retatrutide Background Retatrutide (LY3437943) is the first GLP-1/GIP/GCG triple agonist to complete phase 2 trials, with phase 3 studies ongoing for obesity and/or T2D management