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In the intracellular domain, the sharp kink around the conserved Pro 6.47b -X-X-Gly 6.50b motif in TM6 pivoted the intracellular half of TM6 to move outwards by 18.4 (measured by C carbon of K346 6.35b ), to the same extent as that achieved by orthosteric agonists (Supplementary Fig

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[DOI] [PMC free article] [PubMed] [Google Scholar] 171.Liu J., et al

[1] [3] Zepbound is not approved for use in pediatric patients, and should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus