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De Giorgi and colleagues present a comprehensive analysis of pre-clinical and clinical studies examining the role of glucagon-like peptide-1 receptor agonists in mental disorders.

Phase 3 programmes also evaluated long-term safety, tolerability, and metabolic outcomes, forming the basis for subsequent regulatory approvals in certain jurisdictions
Clinical trials (ten studies, 419 participants) using doses from 400 mg to 10 g over 21 days to 20 months show consistent reductions in fasting glucose, post-meal glucose, and HbA1c. In diabetic animal studies, gymnema increased proglucagon gene expression (a precursor for GLP-1) and insulin gene activity, suggesting it may help amplify endogenous GLP-1 production

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