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First and foremost is diet and exercise

Leptin does not mediate hypertension associated with human obesity
Urticaria was not accompanied by respiratory, cardiovascular or gastrointestinal symptoms and disappeared spontaneously after the drug administration had stopped

All clinical data cited comes from published Phase 2 and Phase 3 trial results and press releases from ongoing studies
Those risk factors include a personal or family history of medullary thyroid cancer and a diagnosis of multiple endocrine neoplasia syndrome type 2 (MEN2)
