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Phase 1: Weeks 1 to 2 (acclimation) The first two weeks establish that the skin tolerates the protocol
By hitting all three receptors, retatrutide aims for a larger impact than previous drugs that only target one or two

it reflects normal digestive physiology responding to slower food movement

When these peptides attach to their respective receptors in the ARC, they activate anorexigenic proopiomelanocortin (POMC) neurons and stimulate POMC processing resulting in -melanocyte-stimulating hormone (-MSH) release [6, 7] leading to satiety, primarily via -MSH-mediated activation of melanocortin 3 and 4 receptors [810]
