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Huang Z, Liu L, Zhang J, Conde K, Phansalkar J, Li Z, et al
doi: 10.1210/en.2007-0966
It hits three receptors at once: GLP-1 (cuts appetite, slows stomach), GIP (improves insulin signaling), and glucagon (raises energy expenditure and fat mobilization)
From the mechanistic perspective, it reminds me the worsening of the peripheral neuropathy throughout rapid insulin-therapy mediated improvement of the glucose control
Clinical guidelines almost always back beginning low and titrating up as tolerated
