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Drug appraisal: Wegovy in metabolic liver disease [Review expected November 2025]

Eating on semaglutide Semaglutide reduces appetite more gradually and affects food preferences differently

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Longer term goals focus on sustainable weight loss of up to 20% of starting body weight typically accompanied with major improvements in diabetes, joint pain, sleep apnea, and cardiovascular health

However, gastroenterologist Eric Goldstein tells Insider, "What this illustrates is any medication, even when used appropriately, may have other changes or side effects that need to be monitored by the patient and the doctor." He also explained that having diarrhea after being constipated is called the "dam breaking phenomenon, which is what you'd expect from taking a ton of laxatives." Sometimes, the liquid stool can seep past the blockage, which is referred to as overflow or paradoxical diarrhea