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Most patients start at a low dose and increase gradually over 1620 weeks
9 GLP-1RAs should not be prescribed in patients with a history of pancreatitis, a personal or family history of medullary thyroid cancer, or multiple endocrine neoplasia due to the observed development of thyroid tumors in animal studies

The SURMOUNT-1 study was a placebo-controlled 72-week trial in obese subjects that randomized 2,539 participants without diabetes into four equally large study arms with placebo or one of the three tirzepatide doses (5, 10, or 15 mg once weekly)

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Second, IR exists in the brains of patients with diabetes mellitus, AD, and PD and is also a factor affecting these mechanisms
