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But behind the hype is a much deeper issue: rising rates of insulin resistance, weight gain, and type 2 diabetes are signaling a metabolic crisis

doi: 10.1503/cmaj.101281 Summary Keywords sodium-glucose cotransporter 2 inhibitors, glucagon-like peptide-1 receptor agonists, type 2 diabetes, metformin, meta-analysis Citation Deng R, Mei K, Song T, Huang J, Wu Y, Yu P, Yan Z and Liu X (2024) First-line treatment with sodium-glucose cotransporter 2 inhibitors and glucagon-like peptide-1 receptor agonists in type 2 diabetic population at low risk of cardiovascular disease: a meta-analysis

Vomiting A total of 23 trials were evaluated regarding the risk of vomiting in patients receiving GLP-1 RAs

After the termination of GLP-1 infusion, urine was collected at 40, 50 and 60 min

Therefore, in addition to the benefits of general weight loss, antidiabetic medications may have therapeutic potential as disease-modifying agents to halt or reverse osteoarthritis at a cellular level