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Risk of bias: all four RCTs were rated low risk by RoB2 (with some concerns for open-label outcome ascertainment in three trials, a domain-specific issue that does not alter the overall RoB2 category from low)

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When these drugs activate those receptors, they appear to: Reduce neuroinflammation Improve the brain's ability to clear amyloid and tau Protect connections between neurons Improve brain insulin sensitivity Before you run to your doctor: The nuance matters here

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