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Polly says Piper started with weight loss treatment, but the company is transitioning to Polly to build a broader wellness ecosystem that includes healthy aging, menopause care, longevity, and hormonal support

As nausea is a common side effect, dietary changes should be reviewed vigilantly

Gastrointestinal side effects such as nausea, vomiting, or diarrhea can lead to fluid losses, while decreased appetite may reduce overall fluid intake

The personalized treatment plan flags the combination, ensures dose timing makes sense, and adjusts the titration schedule to minimize overlapping GI symptoms

One study found that postprandial GLP-1 responses were a significant predictor of T2DM remission after RYGB (163), yet another found similar postprandial GLP-1 responses 2 years after VSG whether the patients had postoperative remission, relapse, or lack or remission of T2DM (107)