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An increase in oxidative stress and ROS production play a role in mitochondrial DNA damage, respiratory impairment, and calcium imbalance, where all these symptoms of mitochondrial dysfunction are associated with AD

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Consider reducing or stopping other diabetes or blood pressure medications if the patient is close to target

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For patients with well-controlled Graves disease who are euthyroid on antithyroid medications or following definitive treatment (radioactive iodine or thyroidectomy), tirzepatide may be considered if there are appropriate indications such as type 2 diabetes or obesity (BMI 30 kg/m or 27 kg/m with weight-related comorbidities)

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