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An increase in oxidative stress and ROS production play a role in mitochondrial DNA damage, respiratory impairment, and calcium imbalance, where all these symptoms of mitochondrial dysfunction are associated with AD

Consider reducing or stopping other diabetes or blood pressure medications if the patient is close to target

This could relate to different pharmacokinetic profiles, lower peak drug levels, or differences in how the oral versus injectable forms interact with the nervous system
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For patients with well-controlled Graves disease who are euthyroid on antithyroid medications or following definitive treatment (radioactive iodine or thyroidectomy), tirzepatide may be considered if there are appropriate indications such as type 2 diabetes or obesity (BMI 30 kg/m or 27 kg/m with weight-related comorbidities)
