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Description
Without resistance training, creatine provides some cellular-level benefits (cell volumization, hydration), but the majority of its muscle-preserving effects depend on being combined with exercise that challenges your muscles

doi: 10.1001/jama.2018.14433

The higher pH protects the peptide from pepsin degradation, which requires acidic conditions

Fabian said.
Among men, use was more common in less advantaged groups, while among women, use was relatively consistent across socioeconomic strata