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Li Z, Jiang YY, Long C, Peng X, Tao J, Pu Y, et al

111 The only acceptable alternative endpoint in drug development, histological evidence, consists of the resolution of steatohepatitis and no worsening of liver fibrosis, or improvement in liver fibrosis of at least one stage without worsening of steatohepatitis

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slow, stepwise titration guided by clinical response and tolerance at each dose level Administration Subcutaneous injection under medical supervision and with physician-prescribed titration schedule

Interestingly, the suppression of GLP-1 secretion by ketone bodies, such as -hydroxybutyrate, was shown to be sensitive to pertussis toxin, implicating the involvement of SCFA receptors, including GPR41/FFAR3 (Wallenius et al., 2020)