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While this persistence rate is a marked improvement over the 10% observed for obesity-indicated GLP-1s, it still leaves 76% of potential demand unrealized

104,105 The activation of GLP-1R may enhance the brains capability to cope with stress by facilitating the release of neurotransmitters and managing the stress response, potentially mitigating both cognitive and emotional challenges related to aging

Meanwhile, just 2.8% of semaglutide users reported any levels of depression that required evaluation by a mental health professional during treatment compared with 4.1% of placebo users

Although the mechanisms leading to a blood pressure decrease during the treatment with GLP-1 agonists have not been fully elucidated it could be the result of an increased sodium and water excretion and/or inhibition of the RAAS activity 14