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doi: 10.1016/j.jacl.2023.10.011

M.ProotP.ChiangY.StumvollM.Del PratoS.et al (2019)

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Trulicity (dulaglutide) is a GLP-1 receptor agonist manufactured by Eli Lilly: FDA approval: 2014 for Type 2 diabetes Dosing: Weekly subcutaneous injection (0.75mg, 1.5mg, 3.0mg, or 4.5mg) Device: Single-use, disposable pen with hidden needle Mechanism: Activates GLP-1 receptors to improve blood sugar control and reduce appetite Trulicity was one of the earlier weekly GLP-1 medications and gained popularity partly due to its user-friendly injection device

Retatrutide is an investigational triple receptor agonist that simultaneously activates GLP-1, GIP, and glucagon receptors to reduce appetite, improve insulin secretion, and increase energy expenditure