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Efficacy and safety of injectable deoxycholic acid for submental fat reduction: a systematic review and meta-analysis of randomized controlled trials

MEDI0832 (now known as cotadutide) is a balanced co-agonist based on the peptide sequence of glucagon, modified at specific amino acid positions in addition to a palmitic fatty acid side chain to prolong activity

The FDA has approved these agents based on extensive clinical trial data, but post-marketing surveillance continues to refine our understanding of their safety profile, including gastrointestinal and hepatobiliary effects

This effect begins with the very first dose, though it strengthens over subsequent weeks as drug levels accumulate

Available online: [DOI] [PMC free article] [PubMed] [Google Scholar] 8.US Preventive Services Task Force