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Contrave is not appropriate for patients with seizure disorders (bupropion lowers the seizure threshold), eating disorders such as bulimia or anorexia, current opioid use or opioid dependence (naltrexone blocks opioid receptors), uncontrolled hypertension, patients taking MAO inhibitors, or women who are pregnant or planning to become pregnant

Curr Diabetes Rep (2018) 18(7):45

Degradation of endogenous and exogenous gastric inhibitory polypeptide in healthy and in type 2 diabetic subjects as revealed using a new assay for the intact peptide

[DOI] [PubMed] [Google Scholar] 753.Salinas C.B.G., Lu T.T., Gabery S., Marstal K., Alanentalo T., Mercer A.J

A patient with favorable GLP1R variants might excel on semaglutide, while another with strong GIPR expression benefits more from tirzepatide's dual action