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Glucagon-like peptide-1 receptor agonists (GLP-1RAs), such as semaglutide and tirzepatide, have emerged as transformative agents for type 2 diabetes and obesity through their potent effects on weight reduction, insulin sensitivity, and cardiovascular outcomes

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Evidence-based comparison of ribupatide (dual GLP-1/GIP agonist) and tirzepatide (dual GIP/GLP-1 agonist), including injectable, oral, and Phase 3 KaiNETIC program data.

But a new large study suggests they both raise and lower the risk, with the lower risk from alcohol reduction:

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