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This increase may lead to a reduction in the projection of the neural repair protein GLP-1, subsequently downregulating the expression of c-Fos, TrkB, and BDNF

doi: 10.1300/J069v23n03_04

A separate 2023 meta-analysis of 18 placebo-controlled trials (1,788 participants) found that berberine reduced LDL cholesterol by about 18 mg/dL, total cholesterol by about 19 mg/dL, and triglycerides by about 30 mg/dL

3 The clinical data obtained in the testing phases is then scrutinized for possible benefits and potential risks

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