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Systemically administered NR may be metabolized in the liver or rapidly hydrolyzed in the blood or intestinal tract and taken up by organs as NAM [43,173,174]

Single vial tirzepatide (Zepbound) rollout Eli Lilly has launched single dose vials of tirzepatide (Zepbound) a dual GLP-1/GIP agonist approved for obesity and sleep apnea treatmentoffering a more accessible and flexible self-pay option

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* Ozempic has a boxed warning for the risk of thyroid cancer

Detailed equations for these methods are provided in Table S5
