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Whereas large molecules like peptides and proteins generally have difficulties accessing the brain, many small molecules have unlimited access to the entire brain

Psychiatric adverse events associated with semaglutide, liraglutide and tirzepatide: A pharmacovigilance analysis of individual case safety reports submitted to the EudraVigilance database

2017;93(3):606-15 e3

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He was spurred to leave medicine and learn about drug development by the discovery in the mid-1990s of leptin, a hormone that suppresses appetite and appeared to be a promising obesity treatment