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Abstract Semaglutide is often optimized to maximize weight loss, yet it remains unclear whether long-term cardiovascular benefit is more closely associated with achieved weight reduction or therapeutic exposure

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More widespread use of SGLT2i in type 1 diabetes will necessitate implementation of strategies to assess and mitigate DKA risk, including preventative measures, patient education and continuous ketone monitoring, as well as a better understanding of the potential benefits for clinical cardiorenal outcomes, especially in high-risk populations such as people with CKD (Table 2) [46, 47]

Protocols often follow a gradual escalation approach to support tolerance and minimize side effects

It has been suggested that in obese patients, these adipokines act peripherally, causing lipid accumulation, lipotoxicity, endoplasmic reticulum stress, mitochondrial dysfunction, and ultimately, cell apoptosis [111,112,113]