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Weight loss from semaglutide is durable as long as you continue treatment, but stopping the medication without lifestyle changes often results in weight regain over months

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This might include: Keeping a detailed symptom diary during semaglutide initiation Establishing thresholds for concerning symptoms (bloody stools, fever, severe pain) Planning for prompt fecal calprotectin testing or limited sigmoidoscopy if symptoms worsen Scheduling more frequent follow-up during the first 3-6 months of therapy Alternative treatment options should be explored