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Some patients report mood changes whilst taking GLP-1 medications, and common side effects such as nausea may increase anxiety in susceptible individuals
Therefore, it is speculated that GLP-1 can indirectly affect bone metabolism by regulating the level of blood glucose (Terzi et al., 2015)

The SURMOUNT and SURPASS trials showed tirzepatide may produce greater weight loss than semaglutide at comparable doses
