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It is suspected that they modulate miRNA involved in lipid metabolism, such as miR-200b, miR200c, miR-34a, miR-338, and miR-21, and induce activating lipid metabolic enzymes [131]

Similarly, the GIPR rs1800437 variant modulates glucose-dependent insulinotropic peptide sensitivity, a pathway that enhances semaglutide's metabolic effects in some individuals
