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The mechanism is well-understood

In patients taking GLP-1 RAs or similar weight loss medication, wrinkles become more prominent, and the skin starts to sag in areas such as the temples, cheeks, tear troughs, jawline, marionette lines, and nasolabial folds

Check body composition, fat distribution and look for muscle wasting

This reduced food intake, if not carefully managed with a well-balanced diet, may result in lower nutrient consumption, potentially leading to deficiencies over time

Sleep apnea, unmanaged thyroid disease, polycystic ovary syndrome (PCOS), and untreated depression all independently slow weight loss and can mask medication effectiveness