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Tirzepatide (Zepbound, FDA-approved for weight management) functions as both a GLP-1 and glucose-dependent insulinotropic polypeptide (GIP) receptor agonist

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Additionally, the presence of a threoninol moiety at the C-terminus necessitates the use of nonconventional SPPS strategies, particularly in the choice of resin, linker and cleavage solution

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