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According to American Diabetes Association guidelines, diabetes is diagnosed when A1C 6.5%, fasting plasma glucose 126 mg/dL, 2-hour plasma glucose 200 mg/dL during an oral glucose tolerance test, or random plasma glucose 200 mg/dL with classic symptoms

These include favorable effects on heart and brain health and decreased diabetes risk [55,56]

However, lack of long-term adherence to lifestyle modifications and adverse side effects, poor bioavailability, rapid clearance, and instability of many approved medicines make obesity and diabetes management challenging

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