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For renal safety, Rybelsus can be used in patients with an eGFR greater than 30 mL/min, while metformin is contraindicated when eGFR drops below 30 and requires dose reduction between 30-45 mL/min

Long-term success depends on sustaining healthy lifestyle practices, such as following a balanced, calorie-conscious diet, engaging in regular exercise, and practicing mindful eating
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Refined food addiction: a classic substance use disorder