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J Headache Pain 63(5):601610 Zelissen PM et al (1991) Calcitonin gene-related peptide in human obesity

Clinical trials show it can produce up to 22.5% body weight reduction under medical supervision

Overall, the deterministic analysis indicated that the total cost of tirzepatide was EUR 2444.02 (76.34%) more than that of semaglutide over the same treatment period (Supplementary Figure S2)

Its mechanism involves stimulating the pituitary gland to produce growth hormone through the body's own natural processes, rather than introducing synthetic hormone directly as direct HGH injections do