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It really needs to be used responsibly. Risks and Side Effects Despite the salutary effects of GLP-1 drugs, most people dont take them for long

Global Burden of Obesity in 2005 and Projections to 2030

In particular, the multiple metabolic actions of glucagon highlight the importance of understanding the contributions of individual hormone action to inform the safe, effective and tailored use of GLP-1/glucagon co-agonists to target weight loss and metabolic disease in the future

Liver Int 39(5):941949

He says there's very little data on whether or how the dose should be titrated to wean patients off, or how to adjust when your appetite and cravings start to return